Endocrine Abstracts

Background: Delta-like ligand 3 (DLL3) is highly expressed on small-cell lung cancer (SCLC) tumors and neuroendocrine carcinomas (NECs). BI 764532 is a DLL3/CD3 IgG-like T-cell engager with potent preclinical activity. NCT04429087 is an ongoing phase I dose-escalation trial of BI 764532 in adults with locally advanced/metastatic DLL3-positive (confirmed centrally) SCLC, extrapulmonary NEC, or large cell neuroendocrine lung carcinoma. Here we focus on patients with extrapulmona...

Aim: To clarify what arises from the decease of visceral adiposity in Japanese diabetic patients with visceral fat accumulation.Patients: Diabetic patients (n=30) whose visceral fat areas (V), determined with abdominal CT, were larger than 100 cm2.Methods: V was followed at every 6 month, and clinical profiles and course were compared of eight patients (group D), whose changes of V(ΔV=(<i...

Objective: High dose growth hormone (rhGH) regimens (2 to 4 mg/day) have been shown to increase circulating insulin-like growth factor (IGF)-I to supra-physiological levels in human immunodeficiency virus (HIV)-infected patients on combined antiretroviral therapy (CART). This setting may improve immunologic output. However, a high plasma IGF-I concentration has detrimental effects on glucose metabolism, which hampers the use of high dose rhGH regimens.Me...

Aim: To evaluate the effect of PPARG2 Pro12Ala, TNFα G(308)A and G(238)A, LIPC C(-514)T, ACE I/D, SLCO1B1 Val174Ala polymorphism on the response to statins therapy in patients with type 2 diabetes mellitus (T2DM).Methods: We consecutively recruited patients with type 2 DM requiring lipid-lowering therapy according to current guidelines. Patients were started on either atorvastatin 10 or 20 mg. After 12 month of st...

Aim: To analyze the safety, efficacy and dosimetry of Lu-177 labeled prostate specific membrane antigen (PSMA) ligand 617 in patients with progressive metastatic castration-resistant prostate cancer (mCRPC), in comparison with Lu-177 PSMA I&T.Methods: Lu-177 PSMA-617 radioligand therapy (PRLT) was performed in 64 mCRPC patients. The median administered activity per treatment was 6 GBq. Ga-68 PSMA PET/CT was used for patient selection and follow-up. H...

Hypogonadism is difficult to confirm with standard assays. A large proportion of testosterone (T) is bound to sex hormone binding globulin (SHBG) and is biologically inert. Accurate measures of free and biological-available-testosterone (Bio-T) are largely unavailable. In this study we compared formulae calculated from the total testosterone (TT) and SHBG in their ability to predict hypogonadism and/or Bio-T.TT and SHBG were determined by ELISA and Bio-T...

There is a marked disparity between the amount of androstenedione (A) excreted in the urine as testosterone (T) glucuronide and the amount of A-T converted in the systemic circulation indicating that there is considerable production of testosterone within the portal circulation which is extracted by the liver. Our studies have examined the hypothesis that intra-abdominal fat is a major source of testosterone production which might contribute to insulin resistance.<p class=...

Background: The hypothalamic neuropeptides kisspeptin and neurokinin B (NKB) are both obligate for normal gonadotrophin secretion. Studies in patients with loss-of-function mutations in NKB signalling suggest that kisspeptin is functionally upstream of NKB, but this hierarchy is unexplored in healthy men and women. We hypothesised that kisspeptin augmentation of estrogen-induced mid-cycle LH secretion will not be abrogated by pharmacological blockade of NKB.<p class="abste...

Introduction: Radiodine (131I) is widely used in the treatment of patients with thyroid cancer. This therapy is associated with some adverse effects including possible impairment of ovarian function and earlier menopause.Objective: The aim of this study was to evaluate female fertility after treatment with 131I of differentiated thyroid cancer (DTC).Methods: We retrospectively analysed 250 women with DTC treat...

Introduction: Up to 10% of patients with congenital hypogonadotropic hypogonadism (HH) may undergo reversal of hypogonadotropism and some of them even attain normal sperm count in adulthood. However, clinical and molecular genetic features of these patients and the triggers leading to reversal of HH are not well understood. We studied whether Finnish reversal variants displayed a common phenotypic or genotypic feature that would predict the clinical course of HH.<p class="...